• HLA antigen frequencies were studied in 45 patients with ocular cicatricial pemphigoid. HLA-B12 was found to have an increased frequency of 44.4% in patients with ocular cicatricial pemphigoid, which was statistically significant when compared with a frequency of 19.6% in the control population (P < .001 or P < .031 when corrected for the number of antigens tested). The results of this study suggest that there is an immunogenetic susceptibility to the development of ocular cicatricial pemphigoid.
Mondino BJ, Brown SI, Rabin BS. HLA Antigens in Ocular Cicatricial Pemphigoid. Arch Ophthalmol. 1979;97(3):479. doi:10.1001/archopht.1979.01020010229007