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Article
March 1979

The Mechanism of Disc Pallor in Experimental Optic AtrophyA Fluorescein Angiographic Study

Author Affiliations

From the William L. McKnight Vision Research Center, Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine.; Dr Anderson is an RPB William and Mary Greve International Scholar, an award made by Research to Prevent Blindness, Inc.

Arch Ophthalmol. 1979;97(3):532-535. doi:10.1001/archopht.1979.01020010276019
Abstract

• Ascending optic atrophy was produced in 13 eyes of owl monkeys (Aotes trivirgatus) by retinal photocoagulation. Color fundus photography and fluorescein angiography were used to study and document the evolution of nerve head abnormalities. The optic nerve heads were also studied histopathologically. Except in certain instances of early transient (relative) filling defects, normal disc fluorescent patterns were preserved, despite clinically apparent optic nerve head pallor. Sectorial defects did not persist into the later phases of the angiogram.

These findings may suggest a reduced blood flow, but neither angiographic nor histopathologic studies detected a reduced vascularity in the atrophic optic nerve. Pallor of the optic nerve head seems to result from alterations in the tissue reflectance and translucency following axonal loss and glial reorganization rather than from a decreased microvascular bed.

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