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March 1979

Tretinoin and Corneal Epithelial Wound Healing

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco.

Arch Ophthalmol. 1979;97(3):545-546. doi:10.1001/archopht.1979.01020010289022

• The entire corneal epithelium of each of 16 rabbits was removed bilaterally. Tretinoin (vitamin A acid) ointment was applied topically twice daily to the eyes of one half of the experimental animals, and the ointment base alone was applied to the eyes of the other half (the controls). On days 1, 2, and 3 after the removal of the epithelium, the healing of the denuded corneas of the animals receiving tretinoin was significantly (P =.01,.01, and.05, respectively) more advanced than the healing of the corneas of the control animals.