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April 1979

Ocular Effects in Normal Rabbits of Topically Applied LabetalolA Combined α- and β-Adrenergic Antagonist

Author Affiliations

From the Departments of Ophthalmology, California College of Medicine, University of California, Irvine (Drs Leopold and Wei and Mr Murray), and Mount Sinai School of Medicine, City University of New York (Dr Podos).

Arch Ophthalmol. 1979;97(4):723-726. doi:10.1001/archopht.1979.01020010375021

• The ocular effects in rabbits of topically applied labetalol hydrochloride, a new α- and β-adrenergic receptor blocking agent, were studied. A dose-related reduction in intraocular pressure (IOP) followed treatment with 0.01% to 1% solutions. Labetalol at a 1% concentration had no effect on pupil diameter. The same dose blocked an increase in IOP after water loading but did not significantly alter the coefficient of aqueous outflow facility. Mydriasis induced by phenylephrine hydrochloride was competitively inhibited.