• In seven patients who each had either a methyl methacrylate corneal shell, a postenucleation ocular prosthesis, or a keratoprosthesis, giant papillary conjunctivitis of the tarsus of the upper lids developed after prolonged wear. These cases expand the spectrum of disease that was initially described in wearers of hard and soft contact lenses. The papillary changes in prostheses wearers did not always produce symptoms and were not readily reversible. Basophils and mast cells characterized the inflammatory infiltrate, suggesting an antigen-antibody mechanism underlying the response. Increased production of epithelial mucin, in contrast to goblet cell mucin, may play a role in producing symptoms in this syndrome.
Srinivasan BD, Jakobiec FA, Iwamoto T, DeVoe AG. Giant Papillary Conjunctivitis With Ocular Prostheses. Arch Ophthalmol. 1979;97(5):892-895. doi:10.1001/archopht.1979.01020010450011