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To the Editor.
—In a recent issue of the Archives (96:1897-1901,1978) Vaughn et al described their experimental data on the perfusion of the anterior chamber of rabbits with carbachol. They noted transitory but reversible swelling of the cornea, which implied some transitory endothelium dysfunction. However, they advised caution in using this solution in humans in whom the cornea has already compromised endothelial cells.In the past two years, the National Registry of Drug-Induced Ocular Side Effects has had numerous reports of patients having transitory and even persistent corneal edema after the use of this drug intraocularly to induce miosis. In the majority of cases of persistent corneal edema that have
Fraunfelder FT. Corneal Edema After Use of Carbachol. Arch Ophthalmol. 1979;97(5):975. doi:10.1001/archopht.1979.01020010513033