• Fifteen orbital tumors have been evaluated with the fine-needle aspiration biopsy (FNAB) technique. The best indication for FNAB is supposed malignant orbital disease. The technique has not been helpful in tumors or inflammatory disease with a high fibrous content. Lesions that are suspected of being pseudotumors are not recommended for FNAB since, even in histologic sections, they are notoriously difficult to distinguish from well-differentiated lymphocytic malignant lymphoma. Benign encapsulated tumors should not be subjected to FNAB.
Kennerdell JS, Dekker A, Johnson BL, Dubois PJ. Fine-Needle Aspiration BiopsyIts Use in Orbital Tumors. Arch Ophthalmol. 1979;97(7):1315-1317. doi:10.1001/archopht.1979.01020020057013