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Article
October 1979

Ocular Manifestations of Familial High-Density Lipoprotein Deficiency (Tangier Disease)

Author Affiliations

From the Clinical Branch (Drs Chu and Cogan), and the Laboratory of Vision Research (Dr Kuwabara), National Eye Institute, and the Molecular Disease Branch, National Heart, Lung, and Blood Institute (Drs Schaefer and Brewer), National Institutes of Health, US Department of Health, Education, and Welfare, Bethesda, Md.

Arch Ophthalmol. 1979;97(10):1926-1928. doi:10.1001/archopht.1979.01020020374020
Abstract

• Corneal clouding is one of the manifestations of Tangier disease, an inherited disorder in which cholesterol-rich lipids are deposited in various tissues of the body. The cause of the corneal clouding is unknown. This study documents the clinical course and conjunctival biopsy findings of a 60-year-old man who was one of the earliest patients to be recognized with Tangier disease and in whom progressive corneal clouding developed in adult life. Noteworthy in the biopsy specimens were birefringent lipid particles that were predominantly present in degenerating pericytes of the conjunctival vessels.

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