• Kinetic vitreous fluorophotometry was used to measure dynamic alterations in blood-retinal barrier function. Normal hooded rats were compared with diabetic animals before and after insulin treatment. Rats with streptozocin-induced diabetes demonstrated significantly longer (P.001) half-periods of fluorescein loss from the vitreous when compared with controls, and insulin treatment significantly reduced (P <.001) the mean halfperiod toward control values without normalization of serum glucose. These results suggest that kinetic vitreous fluorophotometry is a good indicator of bloodretinal barrier function and that sufficient amounts of insulin may be more important than normal blood glucose levels in recovery of altered barrier function in diabetes.
Jones CW, Cunha-Vaz J, Zweig KO, Stein M. Kinetic Vitreous Fluorophotometry in Experimental Diabetes. Arch Ophthalmol. 1979;97(10):1941-1943. doi:10.1001/archopht.1979.01020020389025