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October 1979

Inflammatory Pseudotumor

Arch Ophthalmol. 1979;97(10):1994. doi:10.1001/archopht.1979.01020020410031

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To the Editor.  —The article of Mottow and Jakobiec on inflammatory pseudotumor in childhood (Archives 96:1410-1417, 1978) presented some valuable insights into the nature and course of the disease. Unfortunately, they neglected to subject their conclusions to statistical analysis. It is claimed that the left orbit is involved more often than the right; in fact, it is stated that the left orbit is involved twice as often as the right. Statistical analysis of the data, however, fails to support these conclusions.Twenty-six pediatric patients initially manifested unilateral orbital pseudotumor. There were nine right orbits involved and 17 left orbits. This is the basis of the claimed preponderance of left-side involvement, and the stated 2:1 frequency ratio.Consider the 26 patients as a binomial frequency distribution. If the probability of left-side orbital involvement equals the probability of rightside involvement and equals one half, then the expected number, of, say, left orbits

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