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Article
December 1979

Lissamine Green Staining in the Clinical Diagnosis of Xerophthalmia

Author Affiliations

From the Nutritional Blindness Prevention Project, Bandung, Indonesia (Drs Emran and Sommer), and the Wilmer Institute, Johns Hopkins Hospital, Baltimore (Dr Sommer).

Arch Ophthalmol. 1979;97(12):2333-2335. doi:10.1001/archopht.1979.01020020549009
Abstract

• Lissamine green staining of the conjunctiva, a new and widely heralded aid for diagnosing early xerophthalmia, was found to be a reasonably specific but inadequately sensitive test for practical use. While 82% of clinically normal children failed to show staining, so did 57% with night blindness, 29% with vitamin A responsive Bitot's spots, and, most significantly, 26% with severe, vitamin A related corneal involvement. The test also failed to distinguish vitamin A responsive "Bitot's spots" from nonresponsive ones.

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