[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.204.95.166. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1980

Timolol and EpinephrineA Clinical Study of Ocular Interactions

Author Affiliations

From the Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1980;98(3):484-486. doi:10.1001/archopht.1980.01020030480008
Abstract

• In a crossover design study, we assessed effects on intraocular pressure, pupillary diameter, pulse rate, and blood pressure over six hours of one drop of 0.5% timolol maleate and 2% epinephrine hydrochloride in one eye. Both eyes of each patient had been pretreated for one week with twice-daily applications of epinephrine or timolol, respectively. In random sequence, 20 patients (40 eyes) participated in both phases of the study. Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol. Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.

×