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March 1980

Ocular Neovascularization

Arch Ophthalmol. 1980;98(3):574. doi:10.1001/archopht.1980.01020030570027

To the Editor.  —Ocular neovascularization (NV) is a dreaded complication because of its serious consequences. Although it is well known, its pathogenesis still remains an enigma. The frequent occurrence of NV of the retina, optic disc, and iris in the same group of diseases naturally suggests common causative factors. Over the last four decades, the most favored theory explaining ocular NV has been of anoxia as a stimulus, and a large volume of literature exists on the subject. Liberation of a vasoproliferative factor by hypoxic retina and development of NV of the optic disc, retina, iris, and angle of the anterior chamber in response has been postulated.1-4 Numerous experimental attempts have failed to produce NV as seen in man. Corneal NV in rabbits has been produced by implanting V2 tumor and is thought to be due to a tumor angiogenesis factor,5 with the vitreous exercising an inhibitory

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