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Article
April 1980

Cefaclor Levels in Human Aqueous Humor

Author Affiliations

From the Departments of Medicine (Dr Axelrod) and Ophthalmology (Dr Kochman), St Luke's Hospital Center, New York.

Arch Ophthalmol. 1980;98(4):740-742. doi:10.1001/archopht.1980.01020030734019
Abstract

• In an attempt to investigate penetration of cefaclor into human aqueous humor, we administered 500-mg and 1-g doses of cefaclor to 39 patients about to undergo cataract extraction. Average aqueous humor levels of 0.27, 0.27, and 0.17 μg/mL were achieved at 1, 2, and 4 hours, respectively, after the 500-mg oral dose. After 1 g orally, we found average aqueous humor levels of 0.61, 0.64, 0.72, 0.4, and 0.31 μg/mL at 1, 2, 3, 4, and 5 hours, respectively. Therapeutic levels in primary aqueous humor were consistently achieved against Streptococcus pneumoniae and St pyogenes, group A.

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