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April 1980

Cefaclor Levels in Human Aqueous Humor

Author Affiliations

From the Departments of Medicine (Dr Axelrod) and Ophthalmology (Dr Kochman), St Luke's Hospital Center, New York.

Arch Ophthalmol. 1980;98(4):740-742. doi:10.1001/archopht.1980.01020030734019

• In an attempt to investigate penetration of cefaclor into human aqueous humor, we administered 500-mg and 1-g doses of cefaclor to 39 patients about to undergo cataract extraction. Average aqueous humor levels of 0.27, 0.27, and 0.17 μg/mL were achieved at 1, 2, and 4 hours, respectively, after the 500-mg oral dose. After 1 g orally, we found average aqueous humor levels of 0.61, 0.64, 0.72, 0.4, and 0.31 μg/mL at 1, 2, 3, 4, and 5 hours, respectively. Therapeutic levels in primary aqueous humor were consistently achieved against Streptococcus pneumoniae and St pyogenes, group A.