[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
July 1980

Choroidal Melanoma

Author Affiliations

Washington, DC

Arch Ophthalmol. 1980;98(7):1298-1301. doi:10.1001/archopht.1980.01020040150028

To the Editor.  —Drs Manschot and van Peperzeel (Archives 98:71-77, 1980) have presented a model based on tumor doubling time for the study of uveal melanomas. While we find this kind of model useful in trying to understand the behavior of tumors, we believe that theirs is an oversimplification and that some of the assumptions they have built into the model are not applicable to uveal melanomas. Unfortunately, these simplifications and assumptions profoundly affect the conclusions reached regarding the behavior of uveal melanomas.The first assumption we question is that melanomas in metastatic sites grow at the same rate as does the primary intraocular tumor. From our experience with cases that underwent autopsy in which death occurred before any therapy, we know that metastatic tumors grow faster than the primary intraocular melanoma. In these cases,1 the metastases have grown to a combined weight of several kilograms, while the intraocular

First Page Preview View Large
First page PDF preview
First page PDF preview