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August 1980

Cataract Formation

Author Affiliations

Woodbury, Tenn

Arch Ophthalmol. 1980;98(8):1487. doi:10.1001/archopht.1980.01020040339025

To the Editor.  —Skalka and Prchal, in a recent article (Archives 98:269-273, 1980), reported activity of erythrocyte galactokinase (GK) and galactose-1-phosphate uridyl transferase (GPUT) in a large group of patients with advanced cataract formation. Reduction of activity of at least one of these enzymes was found in a large proportion, nearly half, of those patients with "idiopathic" bilateral cataract formation who were younger than 50 years. I have looked carefully at their data for these patients.For their Table 1 as a whole, there is, surprisingly, no correlation1 between GK activity and GPUT activity (r = −.002). For successive enzymes in a metabolic pathway, such as GK and GPUT, one might have expected some relationship, whether positive or negative.If we look only at the black patients in Table 1, we do find a relationship. The correlation between GK and GPUT for these patients was strong (r =.939, P =.005,

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