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September 1980

Effect of Prazosin on Aqueous Humor Dynamics in Rabbits

Author Affiliations

From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1980;98(9):1639-1642. doi:10.1001/archopht.1980.01020040491021

• Prazosin hydrochloride, a systemic antihypertensive agent, lowers intraocular pressure when applied topically to normal rabbit eyes. A 0.01% solution of topically administered prazosin did not alter outflow facility, episcleral venous pressure, systemic blood pressure, or ocular blood flow. Tonography suggested a 27% decrease in the rate of aqueous humor formation two hours following topical administration. Posterior chamber aqueous ascorbate levels were increased following topical administration of prazosin, which also suggested a decreased entry rate of water into the eye. The effect of prazosin on IOP was prevented by systemic pretreatment with phentolamine mesylate, an α-adrenergic blocking agent, but not by propranolol hydrochloride or atropine sulfate. This was consistent with the known action of prazosin as a postsynaptic αadrenergic blocking agent.