• The intraocular expansion of perfluoromethane (CF4), perfluoroethane (C2F6), and perfluoropropane (C3F8) was determined by a direct method for measuring intravitreal gas. A bubble of CF4 was found to expand 1.9 times the volume initially injected; C2F6 expanded 3.3 times; C3F8 expanded four times. The expansion characteristics of the experimental gases were compared with those of sulfur hexafluoride (SF6) and octofluorocyclobutane (C4F8), two gases already in clinical use.
Lincoff A, Haft D, Liggett P, Reifer C. Intravitreal Expansion of Perfluorocarbon Bubbles. Arch Ophthalmol. 1980;98(9):1646. doi:10.1001/archopht.1980.01020040498023