October 1980

Spindle Cell Carcinoma of the Conjunctiva

Author Affiliations

From the Eye Pathology Laboratory, the Wilmer Ophthalmological Institute, and the Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore (Drs Green, Iliff, and Taxy, Mr Cohen, and Ms de la Cruz); and the Kenya Rural Blindness Prevention Projects, Nakuru (Dr Schwab).

Arch Ophthalmol. 1980;98(10):1809-1813. doi:10.1001/archopht.1980.01020040661014

• Spindle cell carcinoma, a variant of squamous cell carcinoma, has long been recognized in numerous tissues (including the skin, the upper respiratory tract, the oral cavity, and the esophagus). Two cases of spindle cell carcinoma of the conjunctiva are reported here. Histopathologic examination of these cases shows the characteristic spindle-shaped cells in continuity with the overlying epithelium. Electron microscopy of one case showed desmosomes and cytoplasmic tonofibril-like material. Our direct experience with one of these two cases has shown the malignant neoplasm to be aggressive.