To the Editor.
—The article "Iris Neovascular Tufts" (Archives 97:2346-2352, 1979) by Mason includes some interesting observations concerning the prevalence of peripupillary, tuftlike dye leakage in patients with cellular and basement membrane deficiencies. His suggestion that this type of fluorescein extravasate might be a sensitive indicator of local and/or systemic disease confirms similar contentions expressed in recent publications.1.2 It has been shown that tuftlike peripupillary leakage occurs incidentally in a significant number of apparently normal individuals. Thus, 7.31% of subjects younger than 50 years and 30.7% of persons older than this show peripupillary fluorescein leakage in the absence of known ocular or systemic disease.3 The same circumscribed leakage spots are seen in ophthalmic diseases unrelated or previous to possible neovascularization, like recent central retinal vein occlusion, central retinal artery occlusion, glaucomatous eyes receiving miotic or β-blocker treatment, retinal pigmentary dystrophy with posterior pole edema, acute iridocyclitis, and others.
Kottow MH. Iris Neovascular Tufts. Arch Ophthalmol. 1980;98(11):2084. doi:10.1001/archopht.1980.01020040936035