• A 70-year-old man had a sweat gland carcinoma in his right upper eyelid that was slowly growing, but it clinically remained confined to the lid tissues for a period of 25 years. The tumor ultimately extended deeper into the orbit and invaded the sclera, the optic nerve sheath, and the ethmoidal sinuses. Histopathologic examination disclosed malignant features with a variety of cellular patterns. The results of electron microscopic studies confirmed the origin of the tumor from the eccrine sweat glands.
Khalil M, Brownstein S, Codère F, Nicolle D. Eccrine Sweat Gland Carcinoma of the Eyelid With Orbital Involvement. Arch Ophthalmol. 1980;98(12):2210-2214. doi:10.1001/archopht.1980.01020041062013