• Iris angiography and photofluorometry of the aqueous were performed on 44 normal subjects equally distributed between 15 and 65 years of age. Hemoglobin AIc determinations were performed in 20 of these persons. Leakage from the pupillary margin was present in 20% of the eyes studied. In all cases of leakage, the dye faded quickly after the initial peak concentration. No leakage was observed from radial iris vessels. Photofluorometric readings of the aqueous 60 minutes after injection increased significantly with age. Hemoglobin AIc measurements were observed to correlate significantly with aqueous fluorescein concentration. Both these observations may reflect an altered permeability of biologic membranes associated with aging.
Van Nerom PR, Rosenthal AR, Jacobson DR, Pieper I, Schwartz H, Greider BW. Iris Angiography and Aqueous Photofluorometry in Normal Subjects. Arch Ophthalmol. 1981;99(3):489-493. doi:10.1001/archopht.1981.03930010491023