• Visual changes may develop in patients receiving radiation therapy for malignant neoplasms in and about the optic nerve and anterior visual pathway. Cases have been studied using a series of psychophysical tests, including kinetic perimetry, increment threshold determinations, Flashing Repeat Static Test, and sustained- and transient-like functions. A characteristic time-dependent reduction in sensitivity has been identified in these patients. This finding, in addition to the presence of nerve fiber bundle defects, appears to place the pathologic changes in the axon of the ganglion cell posterior to the lamina cribrosa. Any change in the sustained- and transient-like functions, the organization of which appears to be in the neural retina, was seen only if a concomitant radiation retinopathy was identified.
Fitzgerald CR, Enoch JM, Temme LA. Radiation Therapy in and About the Retina, Optic Nerve, and Anterior Visual PathwayPsychophysical Assessment. Arch Ophthalmol. 1981;99(4):611-623. doi:10.1001/archopht.1981.03930010611005