• A 29-year-old white woman had ocular melanocytosis with scleral pigmentation and a diffuse choroidal nevus. The eye was enucleated because of two choroidal tumors. Light and electron microscopy showed two separate choroidal melanomas with different cytologic characteristics. The extreme rarity of multicentric choroidal melanomas supports the belief that ocular melanocytosis predisposes to malignancy.
Pomeranz GA, Bunt AH, Kalina RE. Multifocal Choroidal Melanoma in Ocular Melanocytosis. Arch Ophthalmol. 1981;99(5):857-863. doi:10.1001/archopht.1981.03930010857014