• Uveitis was induced in rhesus monkeys immunized with purified retinal Santigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cellmediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.
Nussenblatt RB, Kuwabara T, de Monasterio FM, Wacker WB. S-Antigen Uveitis in PrimatesA New Model for Human Disease. Arch Ophthalmol. 1981;99(6):1090-1092. doi:10.1001/archopht.1981.03930011090021