[Skip to Content]
[Skip to Content Landing]
Article
July 1981

Polymorphic Amyloid Degeneration of the CorneaA Clinical and Histopathologic Study

Author Affiliations

From the Iowa Lions Cornea Center, Department of Ophthalmology, University of Iowa Hospitals, Iowa City (Drs Mannis, Krachmer, and Pardos), and the Section on Clinical Eye Pathology, Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Md (Dr Rodrigues). Dr Mannis is now with the University of California, Davis; Dr Pardos is now with Mount Sinai School of Medicine, New York.

Arch Ophthalmol. 1981;99(7):1217-1223. doi:10.1001/archopht.1981.03930020091008
Abstract

• The occurrence of polymorphic punctate and filamentous opacities in the axial cornea of patients in the fourth decade of life and older represents a distinct clinical entity. The glass-like deposits are usually in the deeper layers of the cornea and are associated with normal intervening stroma. Although it is not a cause of visual dysfunction, this disorder may be confused with lattice corneal dystrophy or with the corneal deposits in some dysproteinemias. Common clinical findings were found in 14 patients, and these findings were contrasted with the findings in lattice corneal dystrophy. Family studies failed to demonstrate heritability, and lesions were found in older patients only. Histopathologic examination identified the lesions as amyloid. The findings suggest that this disorder should be classified as a corneal degeneration. "Polymorphic amyloid degeneration" is a descriptive term for this condition.

×