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Article
August 1981

Epiretinal and Vitreous MembranesComparative Study of 56 Cases

Author Affiliations

From the Eye Pathology Laboratory, Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore (Drs Kampik, Green, and Michels and Ms de la Cruz); and the Department of Ophthalmology, Harvard Medical School, the Cornea Service, Massachusetts Eye and Ear Infirmary, and the Cornea Research Department and Morphology Unit, Eye Research Institute of the Retina Foundation, Boston (Dr Kenyon).

Arch Ophthalmol. 1981;99(8):1445-1454. doi:10.1001/archopht.1981.03930020319025
Abstract

• Five morphologically distinguishable cell types were observed in 56 epiretinal and vitreous membranes obtained surgically from eyes with various ocular diseases: (1) retinal pigment epithelial (RPE) cells that were evident only in association with retinal detachment, (2) macrophages, (3) fibrocytes, (4) fibrous astrocytes that were characteristic of all disease groups, and (5) myofibroblast-like cells that had mostly the characteristics of fibrocytes and, occasionally, of RPE cells or fibrous astrocytes. The combination of cell types varied in different types of epiretinal membranes, but the formation of collagen and the development of cells with myofibroblast-like properties were common features and seemed to be within the capacity of several cell types. These two common features seem to be the basis for the contractile properties of epiretinal and vitreous membranes.

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