• Two male and four female patients had posterior corneal vesicles and scalloped lesions. Ages ranged from 7 to 24 years. Uncorrected visual acuities were 6/6 or better OU. All cases were unilateral. There was no other ocular abnormality. The lesions were at the level of Descemet's membrane and endothelium. Results of specular microscopic examination suggested that the scalloped lesions could be the result of coalescence of vesicular defects. Several vesicles were surrounded by grayish halos. The remainder of the cornea was normal. Thirty family members were found to be unaffected. These lesions must be differentiated from those in posterior polymorphous dystrophy, congenital glaucoma, and forceps injury. Previous reports have implied a herpetic origin; although their etiologic character is not known, the present study does not support this conclusion.
Pardos GJ, Krachmer JH, Mannis MJ. Posterior Corneal Vesicles. Arch Ophthalmol. 1981;99(9):1573-1577. doi:10.1001/archopht.1981.03930020447008