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Article
October 1981

Ocular Motor Signs in Some Metabolic Diseases

Author Affiliations

From the Clinical Branch, National Eye Institute (Drs Cogan and Chu and Mr Reingold); and the Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md (Dr Barranger).

Arch Ophthalmol. 1981;99(10):1802-1808. doi:10.1001/archopht.1981.03930020676010
Abstract

• Ocular motor disturbances are described with a miscellany of metabolic disturbances. Horizontal gaze abnormalities, often simulating congenital ocular motor apraxia, characterized Gaucher's disease. Vertical gaze abnormalities, especially downgaze paralysis, characterized what is generally considered a variant of Niemann-Pick disease, or sea-blue histiocytosis, but which we prefer to call the "DAF" syndrome. A form of internuclear ophthalmoplegia but with nystagmus of the adducting eye characterized abetalipoproteinemia. Epileptiform eyelid and eye movements occurred in a case of methylmalonohomocystinuria. Ocular motor abnormalities are also described with variation of olivopontocerebellar degeneration and with ataxia telangiecta

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