• Intraocular penetration of moxalactam disodium, a new broad-spectrum oxa-β-lactam antibiotic, was studied in 18 patients undergoing cataract surgery. The antibiotic was administered in a 2-g single dose by intravenous drip during a 20-minute period. After 40 to 230 minutes, moxalactam aqueous humor concentrations ranged from 1.1 to 5.0 μg/mL (mean, 2.3 μg/mL). The ratio of aqueous humor concentrations to concomitant serum concentrations ranged from 1.6% to 9.8%. The achievable aqueous moxalactam concentrations were well above the minimum inhibitory concentrations of most Gram-negative enteric bacilli but not of Pseudomonas and staphylococci.
Uwaydah MM, Jabbour N, Fahd S, Jaafar M, Faris BM. Penetration of Intravenous Moxalactam Into Human Aqueous Humor. Arch Ophthalmol. 1982;100(2):329-330. doi:10.1001/archopht.1982.01030030331023