• The ophthalmic manifestations of a 51-year-old man with multiple myeloma included exudative retinal detachments and multiple epibulbar plasmacytomas. The retinal changes resolved with treatment for systemic effects, and the IgAproducing plasmacytomas rapidly resolved with local irradiation. The young age of onset (37 years), the prolonged course (14 years), and the IgA M protein and epibulbar involvement were, collectively, unusual findings in multiple myeloma. The presence of epibulbar, gastrointestinal tract, and prostate involvement suggested a homing mechanism of IgAcommitted cells to mucosal surfaces.
Franklin RM, Kenyon KR, Green WR, Saral R, Humphrey R. Epibulbar IgA Plasmacytoma Occurring in Multiple Myeloma. Arch Ophthalmol. 1982;100(3):451-456. doi:10.1001/archopht.1982.01030030453015