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April 1982

Fluorometholone AcetateA New Ophthalmic Derivative of Fluorometholone

Author Affiliations

From the Departments of Ophthalmology (Drs Kupferman, Berrospi, and Leibowitz) and Pharmacology (Dr Kupferman), Boston University School of Medicine.

Arch Ophthalmol. 1982;100(4):640-641. doi:10.1001/archopht.1982.01030030642023

• Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis. This is a significantly greater antiinflammatory effect than we have previously reported for the alcohol derivative of fluorometholone and is not significantly different from the therapeutic effect of 1.0% prednisolone acetate ophthalmic suspension, the most effective corneal anti-inflammatory agent that we have studied to date. Fluorometholone acetate (o.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension.