• Forty-four patients with diplopia caused by myasthenia gravis, ocular myopathies, and ocular motor nerve palsies underwent complete orthoptic evaluations before and after intramuscular injection of neostigmine (Prostigmin) methylsulfate. A test score combining the results of binocular and uniocular measurements was developed that allowed correct classification of 70% (31) of patients studied.
Miller NR, Morris JE, Maquire M. Combined Use of Neostigmine and Ocular Motility Measurements in the Diagnosis of Myasthenia Gravis. Arch Ophthalmol. 1982;100(5):761-763. doi:10.1001/archopht.1982.01030030765008