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August 1982

Cryotherapy for Retinoblastoma

Author Affiliations

From the Ophthalmic Oncology Center, New York Hospital-Cornell Medical Center, New York.

Arch Ophthalmol. 1982;100(8):1253-1256. doi:10.1001/archopht.1982.01030040231003

• Cryotherapy was applied to 138 intraocular retinoblastoma tumors from 113 patients who were followed up for a mean of 40 months (four to 144 months). Overall, 70% of tumors were cured with cryotherapy and 93% of patients treated with cryotherapy survived. Twenty-one tumors were treated initially with cryotherapy alone, and 20 such tumors were cured. Twenty-seven new tumors appeared in eyes after radiation therapy and of these, 23 were cured with cryotherapy. Thirty-nine tumors were treated with cryotherapy after unsuccessful treatment with external beam irradiation, and 35 were cured with cryotherapy. Twenty-eight patients developed implantation seeds at the vitreous base after external beam irradiation but cryotherapy failed in each of these cases. There were few long-term ocular complications from cryotherapy despite intensive, heavy, and repeated cryotherapy. The limiting factor that determines success of cryotherapy is the size, elevation, and location of the tumor.