• Cryotherapy was applied to 138 intraocular retinoblastoma tumors from 113 patients who were followed up for a mean of 40 months (four to 144 months). Overall, 70% of tumors were cured with cryotherapy and 93% of patients treated with cryotherapy survived. Twenty-one tumors were treated initially with cryotherapy alone, and 20 such tumors were cured. Twenty-seven new tumors appeared in eyes after radiation therapy and of these, 23 were cured with cryotherapy. Thirty-nine tumors were treated with cryotherapy after unsuccessful treatment with external beam irradiation, and 35 were cured with cryotherapy. Twenty-eight patients developed implantation seeds at the vitreous base after external beam irradiation but cryotherapy failed in each of these cases. There were few long-term ocular complications from cryotherapy despite intensive, heavy, and repeated cryotherapy. The limiting factor that determines success of cryotherapy is the size, elevation, and location of the tumor.
Abramson DH, Ellsworth RM, Rozakis GW. Cryotherapy for Retinoblastoma. Arch Ophthalmol. 1982;100(8):1253-1256. doi:10.1001/archopht.1982.01030040231003