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Article
August 1982

Oral and Topical Treatment of Experimental Herpes Simplex Iritis With Bromovinyldeoxyuridine

Author Affiliations

From the Eye Research Laboratory, Ophthalmological Clinic (Drs Maudgal, Uyttebroeck, and Missotten); and the Rega Institute for Medical Research (Dr De Clercq), Leuven Catholic University, Leuven, Belgium.

Arch Ophthalmol. 1982;100(8):1337-1340. doi:10.1001/archopht.1982.01030040315025
Abstract

• Oral treatment of rabbits with bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]2′-deoxyuridine) at 10 or 100 mg/kg/day for four days significantly reduced the severity of herpes simplex iritis. This effect was not potentiated by the concomitant subconjunctival injection of sustained-action betamethasone. A significant reduction in the severity of herpetic iritis was also observed on topical application of bromovinyldeoxyuridine, and, in this regard, 0.5% bromovinyldeoxyuridine eyedrops proved significantly more efficacious than 1% trifluridine eyedrops.

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