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September 1982

HLA Antigens in Stevens-Johnson Syndrome With Ocular Involvement

Author Affiliations

From the University of Pittsburgh School of Medicine (Drs Mondino, Brown, and Biglan); the Department of Ophthalmology, Eye & Ear Hospital, Pittsburgh (Drs Mondino and Brown); and the Children's Hospital of Pittsburgh (Dr Biglan). Dr Mondino is now with the UCLA School of Medicine, Los Angeles.

Arch Ophthalmol. 1982;100(9):1453-1454. doi:10.1001/archopht.1982.01030040431012

• Fifteen white patients and three black patients with Stevens-Johnson syndrome (SJS) with ocular involvement had HLA typing performed. The HLA-Bw44 antigen was found to have an increased frequency of 66.7% in white patients with SJS with ocular involvement, which was statistically significant when compared with a frequency of 20.4% in the white control population. The results of this study suggest that there is an immunogenetic susceptibility to the development of SJS with ocular manifestations in white patients.