• A 75-year-old man had generalized neurofibromatosis (NFT) with bilateral iris nodules and a mature cataract with elevated intraocular pressure in his left eye. At the time of intracapsular cataract extraction, a sector iridectomy was performed. Electron microscopic studies of the iris nodules within the iridectomy specimen unequivocally established that the spindle-shaped cells within the nodules were of melanocytic origin. We believe that the iris nodules in NFT represent melanocytic hamartomas.
Perry HD, Font RL. Iris Nodules in von Recklinghausen's NeurofibromatosisElectron Microscopic Confirmation of Their Melanocytic Origin. Arch Ophthalmol. 1982;100(10):1635-1640. doi:10.1001/archopht.1982.01030040613012