• A syndrome in which bicolored irides and congenital megacolon were the sole manifestations occurred in three Mexican siblings. Analysis of the pedigree suggested an autosomal recessive mode of inheritance. A neural crest defect may be the basis of this and related syndromes.
Liang JC, Juarez CP, Goldberg MF. Bilateral Bicolored Irides With Hirschsprung's DiseaseA Neural Crest Syndrome. Arch Ophthalmol. 1983;101(1):69-73. doi:10.1001/archopht.1983.01040010071011