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—We have read with interest the communication by Landers and Wolbarsht and agree with their contention that hyperoxygenation may be achieved during radiotherapy by breathing 60% (or 100%) oxygen at normal atmospheric pressure (providing the meager and perhaps secondarily damaged retinal blood supply in a retinoblastoma behaves in a normal manner). With increasing sophistication of positron emission tomography, it may be possible to directly assess oxygen levels in an eye with retinoblastoma with the patient breathing varying levels of oxygen. Alternatively, this thesis could, of course, be assessed clinically by comparing results of treatment with and without hyperoxygenation in combination with hypoxic cell sensitizers. The effect of these modalities would almost certainly be additive and may greatly improve cell kill.
Rootman J. Ocular Absorption-Reply. Arch Ophthalmol. 1983;101(1):134. doi:10.1001/archopht.1983.01040010136030