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March 1983

Serum Immunoglobulins and Uveitis

Author Affiliations

From the Uveitis Service, Department of Ophthalmology (Drs Kahn, Schlaegel, and Weber) and the Department of Medicine (Dr Biegel), Indiana University School of Medicine, Indianapolis.

Arch Ophthalmol. 1983;101(3):458-459. doi:10.1001/archopht.1983.01040010458025

• Sixty-two percent of 975 uveitis patients had a statistically significant elevation in the levels of one or more of three serum immunoglobulins. The percentage of cases of above-normal values was greatest for IgM (43.8%), followed by IgA (34.0%), and then by IgG (11.9%). There was no statistically significant difference in immunoglobulin values obtained for one diagnosis as compared with all others, except for men with HLA-B27. They had a higher percent of elevated IgM values than men with all other diagnoses. Testing for immunoglobulins is of little or no value in the etiologic diagnosis of a single case of uveitis, but may be of value in research studies to better understand its pathogenesis.