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March 1983

Perfluoro-n-ButaneA Gas for a Maximum Duration Retinal Tamponade

Author Affiliations

From the Department of Ophthalmology, New York Hospital-Cornell Medical Center (Mr Lincoff and Drs Lincoff, Iwamoto, and Jacobiec), and the Universitäts-Augenklinik, Tübingen, West Germany (Dr Kreissig).

Arch Ophthalmol. 1983;101(3):460-462. doi:10.1001/archopht.1983.01040010460026

• The behavior of the gas perfluoron-butane (C4F10) in the rabbit vitreous suggests that the gas might be useful as a long-term intravitreal tamponade in retinal detachment surgery. Perfluoro-n-butane was found to expand more and remain in the eye longer than any gas previously reported. A 0.3-mL bubble expanded five times and displaced the entire rabbit vitreous in three days. The volume of the bubble began to shrink after one week, but still filled more than half the eye at three weeks. The time for total disappearance was more than three months.