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Article
April 1983

Effects of Prednisolone and Medroxyprogesterone on Corneal Wound Healing, Ulceration, and Neovascularization

Author Affiliations

From the Department of Cornea Research, Eye Research Institute of Retina Foundation (Drs Phillips, Cintron, and Kenyon and Mss Rose and Kublin), Department of Ophthalmology, Beth Israel Hospital (Drs Arffa and Miller), and the Department of Ophthalmology, Harvard Medical School (Drs Phillips, Arffa, Cintron, Miller, and Kenyon), Boston.

Arch Ophthalmol. 1983;101(4):640-643. doi:10.1001/archopht.1983.01040010640024
Abstract

• Albino rabbits were treated four or six times daily with 1% prednisolone acetate, 1% medroxyprogesterone acetate, or a control vehicle, after one of three conditions. First, after 3-mm linear perforating stromal incisions; drugs were given for seven days, and wound bursting strength was determined. Prednisolone suppressed wound tensile strength by 20%; medroxyprogesterone suppressed it by 11%. Second, after trephination, drug administration for 14 days decreased collagen formation in the scar buttons by 43% in the prednisolone-treated group and 39% in the medroxyprogesterone-treated group. Third, after thermal burns; when drug application followed the burn immediately, deep ulceration or perforation developed in 85% of the controls, in none of the prednisolone-treated group, and in 17% of the medroxyprogesterone-treated group. When drug delivery was withheld until day 6, severe ulceration developed in 44% of both groups. In both experiments, stromal neovascularization was markedly suppressed by prednisolone, but only moderately decreased by medroxyprogesterone.

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