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Article
May 1983

Histoplasmic EndophthalmitisA Clinicopathologic Correlation

Author Affiliations

From the Department of Ophthalmology, Mayo Clinic and Mayo Medical School, Rochester, Minn. Dr Goldstein is now with the Tampa (Fla) Eye Clinic.

Arch Ophthalmol. 1983;101(5):774-777. doi:10.1001/archopht.1983.01040010774016
Abstract

• A patient had a 12-year history of relapsing disseminated histoplasmosis. None of the characteristic lesions of the presumed ocular histoplasmosis syndrome were present in either eye. Ocular involvement began as a peripheral focal retinitis associated with vitreitis and iritis. Histoplasma capsulatum organisms grew in cultures from aqueous and vitreous and were demonstrated histologically in an iridectomy specimen. Despite intraocular and subconjunctival administration of amphotericin B, intractable pain associated with progressive necrotizing granulomatous iridocyclitis necessitated enucleation. Histoplasma capsulatum organisms were seen extracellularly in the vitreous cavity and both intracellularly and extracellularly in areas of granulomatous inflammation involving the iris, ciliary body (diffusely), and the retina (focally). The choroid was not involved.

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