• Forty-eight patients (49 eyes) had nonperforating traumatic hyphema. Twenty-eight patients (28 eyes with hyphema) received oral aminocaproic acid, an antifibrinolytic agent, in a dosage of 100 mg/kg every four hours for five days, up to a maximum daily dose of 30 g. Twenty patients (21 eyes with hyphema) received placebo in an identical regimen. One eye treated with aminocaproic acid rebled; seven eyes receiving the placebo rebled. The results of this study show a statistically significant reduction in the incidence of secondary hemorrhage in the patients receiving aminocaproic acid.
McGetrick JJ, Jampol LM, Goldberg MF, Frenkel M, Fiscella RG. Aminocaproic Acid Decreases Secondary Hemorrhage After Traumatic Hyphema. Arch Ophthalmol. 1983;101(7):1031-1033. doi:10.1001/archopht.1983.01040020033003