To the Editor.
—We read with great interest the article entitled "Intraocular Antiviral Penetration" by Poirier et al, published in the December 1982 Archives (100:1964-1967). We have difficulty understanding the methods used by the investigators because the dosing regimen was not comparable among the three agents under investigation.The dosage of vidarabine monophosphate (3% solution) was 5 drops every six hours for 24 hours before surgery. The last dose was given 30 minutes before surgery. Trifluridine (1% solution) was given as 1 drop every 30 minutes two to three hours before surgery. The last dose was given five minutes before surgery. The recommended dosage is 1 drop every two hours while awake to a maximum of 9 drops in a 24-hour period. Sugar et al1 have recommended 1 drop every five minutes in four doses, yielding levels of 5 to 6 mg/L in the anterior chamber of the eye
Weaver DT, Isenberg SJ. Intraocular Antiviral Penetration. Arch Ophthalmol. 1983;101(7):1146. doi:10.1001/archopht.1983.01040020148031