• Thirteen patients who wore soft contact lenses were seen with a syndrome consistent with superior limbic keratoconjunctivitis. An irregular epithelial surface, punctate staining with fluorescein, and subepithelial infiltrates were found on the superior aspect of the corneas in association with hyperemia of the superior bulbar conjunctivae. The keratoconjunctivitis persisted as long as 15 months after discontinuation of lens wear. Patch testing with ophthalmic vehicle preservatives, performed on seven patients, failed to show a consistent hypersensitivity to any of the tested compounds, and three patients had used only preservative-free saline for lens care. The etiology of this syndrome is unknown.
Fuerst DJ, Sugar J, Worobec S. Superior Limbic Keratoconjunctivitis Associated With Cosmetic Soft Contact Lens Wear. Arch Ophthalmol. 1983;101(8):1214-1216. doi:10.1001/archopht.1983.01040020216010