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To the Editor.
—Are you tired of trying to adequately anesthetize rabbits with pentobarbital alone or in combination with other agents? There is a significant mortality because of the poor therapeutic index of pentobarbital in rabbits. A good combination for intramuscular administration that achieves at least two hours of adequate anesthesia for ocular manipulation including corneal scraping is as follows: 7.5 to 10 mg/kg of ketamine combined with 0.5 mg/kg of acepromazine maleate and 1.5 mg/kg of xylazine administered 15 minutes after initial injection. After more than 30 trials, we have a zero mortality.
Johnson AP, McDonald CN. Rabbit Anesthesia. Arch Ophthalmol. 1983;101(8):1302. doi:10.1001/archopht.1983.01040020304033