• Progressive branching, needlelike stromal opacities were observed within a corneal transplant. Analysis of the corneal button by light microscopy and transmission electron microscopy disclosed a localized epithelial ingrowth into the stroma at a suture tract accompanied by intrastromal pockets of gram-positive cocci extending across the cornea. No inflammatory reaction was found in the areas of bacterial colonization. To our knowledge, noninflammatory bacterial colonization of the stroma of a corneal transplant has not been previously described.
Gorovoy MS, Stern GA, Hood CI, Allen C. Intrastromal Noninflammatory Bacterial Colonization of a Corneal Graft. Arch Ophthalmol. 1983;101(11):1749-1752. doi:10.1001/archopht.1983.01040020751018