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Article
December 1983

Macrophages in Ocular Tissues of RatsDetermination of Their Number After Local Anaphylaxis and Other Procedures

Author Affiliations

From the Departments of Ophthalmology (Dr Allansmith) and Medicine (Dr Bloh), Harvard Medical School, the Department of Cornea Research, Eye Research Institute of Retina Foundation (Dr Allansmith and Mr Baird), and the Clinical Immunology and Allergy Units, Medical Services, Massachusetts General Hospital (Dr Bloch), Boston.

Arch Ophthalmol. 1983;101(12):1930-1934. doi:10.1001/archopht.1983.01040020932021
Abstract

• The number of macrophages in rat ocular tissues was determined, with the tip of the eyelid containing about 3,000 macrophages per cubic millimeter, which is similar to the number of mast cells at this site. Fewer macrophages were present in orbital tissues and conjunctiva. Macrophages accumulated in ocular tissues of immunized rats injected locally with antigen, but the number did not exceed that observed in antigen-injected controls. Injection of various fluids into ocular tissues, but not the trauma of needle punctures alone, stimulated a marked accumulation of macrophages. Thus, the response to nonspecific stimuli masked the macrophage response to antigen-induced, ocular anaphylaxis.

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