• Betaxolol hydrochloride, 0.5%, and timolol maleate, 0.5%, were compared in a 26-week randomized, double-masked study involving 46 patients with primary open-angle glaucoma. The two drugs were comparable with regard to both intraocular pressure-lowering efficacy and side effects. Since betaxolol is a selective β1-adrenergic antagonist, it may be advantageous for patients in whom β2-blockade could be harmful.
Berry DP, Van Buskirk EM, Shields MB. Betaxolol and TimololA Comparison of Efficacy and Side Effects. Arch Ophthalmol. 1984;102(1):42-45. doi:10.1001/archopht.1984.01040030026028